Image of the Month (2010-5)
Use of P63 immunohistochemistry to confirm invasion in a CK5/6 positive grade 1 breast cancer
1cm mass in left breast; clinical invasive cancer; core biopsy showing grade 1 histology
Medium power view
High power detail of above
Strong CK5/6 staining of normal breast duct on left with weaker staining of cancer tubules
Normal duct with strong positive nuclear staining with p63 demonstrating myoepithelial layer. Surrounding tubules of invasive grade 1 cancer are negative.
The weak cytoplasmic staining should be disregarded.
Detail of above - 'Mouse-over' for high power of P63.