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Breast cancer - large central scar following four weeks neoadjuvant letrozole therapy



This feature can be seen in over 50% of cases similarly treated - see reference
'Mouse over' for detail of scar
The tumour measured 18mm.

Breast cancer - large central scar following four weeks neoadjuvant letrozole therapy


Detail of tumour adjacent to scar
'Mouse over' for peripheral vessel showing medial hypertrophy and calcs -
an ischaemic basis has been proposed for such scarring
Breast cancer - large central scar following four weeks neoadjuvant letrozole therapy



Reference:


Thomas JS, Julian HS, Green RV, Cameron DA and Dixon MJ. Histopathogy of breast carcinoma following neoadjuvant systemic therapy: a common association between letrozole therapy and central scarring. Histopathology 2007. 51: 219-226.

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