Genetics of Breast Cancer - Clinico-pathological associations of BRCA mutations

*Association of clinicopathological features among tumours of BRCA1* families, BRCA2 families and non-BRCA1/BRCA2 families compared with tumours from patients with sporadic breast cancer**
	BRCA1 cases			BRCA2 cases			Non-BRCA1/BRCA2			Sporadic

	n	%	P	n	%	P	n	%	P	n	%

All	46			40			358			364
Oestrogen receptor
Negative	33	75.0	<0.0005	15	38.5	0.013	79	24.3	0.294	75	20.9
Positive	11	25.0		24	61.5		246	75.7		283	79.1
Progesterone receptor
Negative	37	84.1	<0.0005	21	53.8	0.014	115	35.6	0.657	122	34.0
Positive	7	15.9		18	46.2		208	64.4		237	66.0
Grade
I	1	2.2	<0.0005	8	20.0	0.933	82	23.5	0.717	81	22.3
II	11	24.4		17	42.5		154	44.1		154	42.4
III	33	73.3		15	37.5		113	32.4		128	35.3
T
1	21	46.7	0.079	18	54.5	0.516	229	65.6	0.144	219	60.3
2 to 4	24	53.3		15	45.5		120	34.4		144	39.7
N
0	32	71.1	0.026	15	44.1	0.289	214	61.1	0.043	193	53.6
1	13	28.9		19	55.9		136	38.9		167	46.4
M
0	41	93.2	0.570	28	90.3	0.245	338	98.8	0.005	335	95.2
1	3	6.8		3	9.7		4	1.2		17	4.8
p53
Negative	25	62.5	0.017	26	76.5	0.707	261	76.5	0.399	267	79.2
Positive	15	37.5		8	23.5		80	23.5		70	20.8
HER2
Negative	30	100	0.017	27	100	0.023	256	85.3	0.598	269	83.8
Positive	0	0		0	0		44	14.7		52	16.2
CK-5/6
Negative	28	82.4	0.250	24	92.3	0.599	289	86.8	0.383	299	89.0
Positive	6	17.6		2	7.7		44	13.2		37	11.0
CK-14
Negative	20	60.6	<0.0005	19	73.1	0.011	257	79.3	<0.0005	294	89.6
Positive	13	39.4		7	26.9		67	20.7		34	10.4
CK-17
Negative	42	97.7	0.866	34	100	0.326	309	96.6	0.624	316	97.2
Positive	1	2.3		0	0		11	3.4		9	2.8
Age (years)
≥50	16	34.8	<0.0005	22	55.0	0.004	215	60.1	0.035	246	67.6
<50	30	65.2		18	45.0		143	39.9		118	32.4
CK, cytokeratin; HER2, human epidermal growth factor receptor 2.
From Eerola et al. Breast Cancer Research 2008 10:R17 doi:10.1186/bcr1863