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Other sclerosing lesions:





- see also 'Radial Scars" and Immunohistochemistry



Sclerosing adenosis




Low power view of a focus of sclerosing adenosis (blue circle) - the background lesion has a vaguely stellate architecture and it is likely that in this case the focus of sclerosing adenosis was part of an early radial scar
Sclerosing adenosis - low power view

Medium power views of a focus of sclerosing adenosis
Sclerosing adenosis - low power view

Sclerosing adenosis - low power view Sclerosing adenosis - medium power view


Low power view of two adjacent nodular foci of sclerosing adenosis
Sclerosing adenosis - low power view


Medium power view of one of the nodules above
Sclerosing adenosis - medium power view
Sclerosing adenosis - low power view Sclerosing adenosis - medium power view

Immunohistochemistry for CK 5/6 showing preservation of myoepithelial layer throghout area of sclerosing adenosis
Sclerosing adenosis - low power view


Unusual variant of sclerosing adenosis - note prominent 'myoid' differentiation of myoepithelial cells demonstrated clearly by smooth muscle actin imunostain
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sclerosing adenosis - example 3 - x10 sclerosing adenosis - example 3 - x20 sclerosing adenosis - example 3 - x40 sclerosing adenosis - example 3 - smooth muscle actin immunostain


Atypical apocrine sclerosing lesion





Atypical apocrine sclerosing lesion
Note overall pattern of a radial scar with superimposed apocrine metaplasia
Atypical apocrine sclerosing lesion - low power view


Atypical apocrine sclerosing lesion - detail showing crowded glands with apocrine atypia
Atypical apocrine sclerosing lesion - detail

Atypical apocrine sclerosing lesion - CK 5/6 staining highlights overall lobular pattern (left); detail (right)
Atypical apocrine sclerosing lesion - low power CK 5/6 Atypical apocrine sclerosing lesion - CK 5/6 - detail


Microglandular adenosis




Microglandular adenosis - low power view showing haphazard arrangement of glands apparently infiltrating stroma
Microglandular adenosis - low power

Microglandular adenosis - ducts lined by a single epithelial cell layer and conaining secretory material. Stroma is non-reactive
Microglandular adenosis - detail Microglandular adenosis - detail

See also Image of the Week 2009-1

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