In this section three lesions are discussed:
- Atypical Ductal Hyperplasia (ADH)
- Columnar Cell Change with atypia
- Atypical Lobular Hyperplasia (ALH)
All three conditions if identified in a core biopsy require at least follow up and usually a diagnostic excision biopsy and all three lesions
confer up to a four or five times increased risk of the long term development of cancer.
Atypical Ductal Hyperplasia (ADH)
- ADH is important because it carries a 4-5 times relative risk of breast cancer at 10-15 yrs post biopsy.
- It causes diffuculty to diagnostic pathologists - inconsistency in diagnosis is common.
- It lies closest morphologically to low grade DCIS - it is NOT a high grade lesion.
The following histological features are recognised: