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Lobular Carcinoma Variants



The following are recognized lobular carcinoma variants:





Tubulo-lobular



Invasive Tubulo-lobular carcinoma - example 1
Typical streaming pattern of classical invasive lobular carcinoma Separate area showing tubular growth pattern but cytologically <i>lobular</i> features


Selected views of a tubulo-lobular breast cancer - example 2
Click on images for further detail



Selected views of a tubulo-lobular breast cancer Selected views of a tubulo-lobular breast cancer
Selected views of a tubulo-lobular breast cancer Selected views of a tubulo-lobular breast cancer

Selected views of a tubulo-lobular breast cancer Selected views of a tubulo-lobular breast cancer

See also Image of the Quarter 2015 No 1


Alveolar




Invasive lobular carcinoma - alveolar variant
The three H&Es show a uniform alveolar growth pattern. E cadherin staining (top right) is negative
Typical streaming pattern of classical invasive lobular carcinoma Single file runs of tumour cells with squared-off edges. Note apparent clear space at cell-cell interface
Small runs of invasive lobular carcinoma (arrows) with two adjacent foci of LCIS

Solid




Invasive lobular carcinoma - solid variant
Core biopsy replaced entirely by solid sheets of variant lobular carcinoma cells Medium power view showing lobular cytological features
Pan cytokeratin to confirm that the cells are epithelial The carcinoma is uniformly E Cadherin negative

Pleomorphic




Invasive lobular carcinoma - Pleomorphic variant - example 1
Typical streaming pattern of classical invasive lobular carcinoma Single file runs of tumour cells with squared-off edges. Note apparent clear space at cell-cell interface
Small runs of invasive lobular carcinoma (arrows) with two adjacent foci of LCIS



Invasive lobular carcinoma - Pleomorphic variant - example 2
Typical streaming pattern of classical invasive lobular carcinoma Single file runs of tumour cells with squared-off edges. Note apparent clear space at cell-cell interface
Small runs of invasive lobular carcinoma (arrows) with two adjacent foci of LCIS


Invasive lobular carcinoma - Pleomorphic variant - example 3
Typical streaming pattern of classical invasive lobular carcinoma Marked nuclear pleomorphism and frequent mitotic figures
Area showing abundant eosinophilic cytoplam characteristic of pleomorphic variant - myoid pattern E cadherin staining negative throughout - pan cytokeratin staining was also carried out and was strongly positive


Lobular Mixed




Invasive lobular carcinoma - Mixed classical and solid patterns
Typical streaming pattern in area showing classical growth pattern Solid area in same tumour
Solid area in same tumour E cadherin staining negative throughout
ER (nuclear) staining strongly positive as is usually the case with lobular carcinomas


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