Case of the month - October 2007
History:
- 60 year old female - Short history of moderately extensive induration of the breast with blotchy skin discolouration - punch biopsy of breast skin taken
- Past history of ipsilateral wide local excision and radiotherapy for breast carcinoma 10 years ago
Low power view of punch biopsy showing a patchy infiltrate throughout the dermis
Medium power view (x10) showing patchy infiltration of entire dermis
Medium power view (x 20) of area 'A' above (papillary dermis)
- note infiltrating spindle cells with cleft-like spaces
Further view of Area 'A'
Solid tumour nodules in deeper dermis (area 'B')
High power views (x 40) - solid nest of malignant spindle cells (red circle) and cleft-like spaces (blue arows)
Solid tumour area upper right ('X') and cleft-like spaces lower left ('Y')
High power views (x 40) of cleft-like spaces lined by atypical spindle cells
