Case of the month - November 2006
- discussion
Diagnosis - Myoid 'hamartoma' of the breast
- Benign proliferative lesion composed of lobules and ducts with intervening bundles of smooth muscle
- Smooth muscle elements stain strongly positively with desmin and smooth muscle actin
'Hamartoma' believed to be a misnoma with the lesion more probably being a variant form of an adenosis tumour. Readers are referred to the excellent discussion by Rosen
Smooth muscle elements derived from myoid metaplasia of myoepithelial elements in sclerosed areas
- In this case immunostains for CK 5/6 and CK14 were negative failing to support this contention.
Glandular elements show a mixture of patterns including sclerosing adenosis, apocrine metaplasia and fibroadenomatoid foci
Prognosis:
- Lesions usually treated by simple excision only
- No tendency to local recurrence
References:
- Rosen PP. Rosen's Breast Pathology. 2nd Edition 2001 Lippincott Williams & Wilkins, Philadelphia. p782-783.
- Mathers ME & Shrimankar J
Lobular Neoplasia within a Myoid Hamartoma of the Breast. The Breast Journal, 2004;10: 58
- Filho OG, Gordan AN, Mello R, Netto CS & Heinke T.
Myoid Hamartomas of the Breast. Report of 3 Cases and Review of the Literature.
Intl J Surg Pathol, 2004; 12, 151-153.
- Tse GMK, Law BKB, Ma TKF, Chan ABW, Pang L-M, Chu WCW and Cheung HS
Hamartoma of the breast: a clinicopathological review. J Clin Pathol 2002;55:951-954.